GENERAL HISTOLOGY

Detailed explanation-1: -Primary hypercortisolism is known as Cushing syndrome. It is the autonomous overproduction of cortisol by the adrenal gland. Common causes include adrenal adenoma, adrenal carcinoma, and adrenal hyperplasia. Secondary hypercortisolism is due to increased ACTH production, which leads to an increase in cortisol.

Detailed explanation-2: -A higher-than-normal level of ACTH may indicate: Adrenal glands not producing enough cortisol ( Addison disease ) Adrenal glands not producing enough hormones ( congenital adrenal hyperplasia ) One or more of the endocrine glands are overactive or have formed a tumor ( multiple endocrine neoplasia type I )

Detailed explanation-3: -Addison’s disease is usually the result of a problem with the immune system, which causes it to attack the outer layer of the adrenal gland (the adrenal cortex), disrupting the production of the steroid hormones aldosterone and cortisol.

Detailed explanation-4: -What is Cushing’s syndrome? Cushing’s syndrome is the result of excessive corticosteroids in the body. The main cause is overproduction of adrenocorticotropin hormone (ACTH) in the pituitary gland. ACTH causes the adrenal glands to produce corticosteroids, so too much of ACTH means too much of corticosteroids.