GENERAL HISTOLOGY

Detailed explanation-1: -Dipsogenic diabetes insipidus (also known as primary polydipsia) happens when there’s an issue with your hypothalamus unrelated to ADH production that causes you to feel thirsty and drink more liquids. Specific causes include: Damage to your hypothalamus from surgery, infection, inflammation, a tumor or a head injury.

Detailed explanation-2: -In a healthy person, AVP acts as a signal to the nephrons to reabsorb water into the body. In nephrogenic diabetes insipidus, the nephrons in the kidneys are not able to respond to this signal, leading to excessive water loss in large amounts of urine. Your thirst increases to try to balance this loss from the body.

Detailed explanation-3: -Diabetes insipidus is caused by a lack of antidiuretic hormone (ADH), also called vasopressin, which prevents dehydration, or the kidney’s inability to respond to ADH. ADH enables the kidneys to retain water in the body. The hormone is produced in a region of the brain called the hypothalamus.

Detailed explanation-4: -Central diabetes insipidus is due to a deficiency in the production of ADH, often resulting from damage to the pituitary gland.