ENDOCRINE SYSTEM
THYROID FOLLICULAR CELL
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Papillary ca
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Follicular ca
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Medullary ca
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Anaplastic ca
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Detailed explanation-1: -The Orphan Annie-eyed clear nucleus, defined as a large, optically clear nucleus, devoid of chromatin strands, with sharp chromatin rim, is a more specific feature than are nuclear grooves or intranuclear cytoplasmic inclusions in papillary thyroid carcinoma.
Detailed explanation-2: -Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, defined by a set of distinctive nuclear features, including: Change of nuclear size and shape: nuclear enlargement, elongation and overlapping. Chromatin characteristics: chromatin clearing, margination and glassy nuclei.
Detailed explanation-3: -They are well encapsulated in an intact capsule, which distinguishes them from follicular carcinoma. The papillary carcinoma shows typical “Orphan Annie eye” nuclei, which are due to finely dispersed chromatin.