GENERAL HISTOLOGY

Detailed explanation-1: -Both occludin and claudin interact with scaffolding proteins (ZO-1, -2, and-3) and occludin interacts with the signalling molecule FAK. These interactions with scaffolding proteins connect occludin and claudin to the actin cytoskeleton and allow localization of cell signalling molecules to tight junctions.

Detailed explanation-2: -Claudin and occludin are major transmembrane proteins of the tight junction that provide tight control over paracellular diffusion within an epithelium. Interestingly, claudin and occludin are often targeted and misplaced by viruses, 1, 6 bacteria, 7, 8 and inflammatory cytokines.

Detailed explanation-3: -The tight junction membrane domain contains at least three distinct proteins, named occludin, claudin and junctional adhesion molecule. Claudins are products of a gene family consisting of more than 20 members.

Detailed explanation-4: -Claudins are tight junction membrane proteins that are expressed in epithelia and endothelia and form paracellular barriers and pores that determine tight junction permeability.