GENERAL HISTOLOGY

Detailed explanation-1: -Large bundles of intermediate filaments extend from the nuclear surface and cell interior out toward the plasma membrane, where they attach to desmosomes by interweaving with the cytoplasmic plaque of the adhesive complex.

Detailed explanation-2: -Desmosomes are one of the stronger cell-to-cell adhesion types and are found in tissue that experience intense mechanical stress, such as cardiac muscle tissue, bladder tissue, gastrointestinal mucosa, and epithelia.

Detailed explanation-3: -Desmosomes link the intracellular network of keratin intermediate filaments to anchor it to apposing keratinocyte cell surface membranes.