GENERAL HISTOLOGY

Detailed explanation-1: -To date two components of the TJ filaments have been identified: occludin and claudin. The latter is a protein family with more than 20 members. Both occludin and claudins are integral proteins capable of interacting adhesively with complementary molecules on adjacent cells and of co-polymerizing laterally.

Detailed explanation-2: -Types of Cell Junctions Figure 1: The three basic types of cell-to-cell junctions are tight junctions, gap junctions, and anchoring junctions. At one end of the spectrum is the tight junction, which separates the cells into apical and basal compartments.

Detailed explanation-3: -The tight junctions between epithelial cells are thought to have both of these roles. First, they function as barriers to the diffusion of some membrane proteins (and lipids) between apical and basolateral domains of the plasma membrane (see Figure 19-2).

Detailed explanation-4: -Occluding junctions Proteins in the membrane of adjacent cells called occludin interact with each other to produce this tight seal. In the cytoplasm of the cell, occludin interacts with the actin cytoskeleton via another proteins called ZO-1.