GENERAL HISTOLOGY

EXCRETORY SYSTEM

KIDNEY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
A full term male neonate has bilateral flank masses and oliguria and is in respiratory distress. A third-trimester ultrasound right before delivery showed severe oligohydramnios. A renal ultrasound of the neonate now shows multiple renal cysts. What is the most likely cause?
A
Autosomal recessive polycystic kidney disease
B
Autosomal dominant polycystic kidney disease
C
Renal agenesis
D
Potter syndrome
Explanation: 

Detailed explanation-1: -Ureteropelvic junction obstruction is the most common cause of obstructive hydronephrosis in neonates and shows a male and left-side predominance [2, 36]. Ureteropelvic junction obstruction can be caused by abnormally developed ureteral smooth muscle at the ureteropelvic junction, resulting in an aperistaltic segment.

Detailed explanation-2: -Among all birth defects that cause hydronephrosis in fetuses and newborns, UPJ obstruction and VUR are most common. Lower urinary tract obstruction. In lower urinary tract obstruction, also called bladder outlet obstruction, a blockage is present in the urethra or where the bladder joins the urethra.

Detailed explanation-3: -Two types of problems cause hydronephrosis. One is obstruction, where urine is physically prevented from draining out of the kidney. The obstruction, or blockage, can occur at any point in the urinary system from the kidney down to the urethra. The second is reflux, in which urine flows back up into the kidney.

Detailed explanation-4: -The most common causes for moderate to severe hydronephrosis are: An obstruction between the kidneys and the urethra that prevents urine from draining properly from the kidneys.

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