GENERAL HISTOLOGY

Detailed explanation-1: -ADH acts on aquaporin-2, a membrane protein that forms gated water channels in the wall of the collecting ducts. These channels allow water to pass rapidly through the plasma membrane.

Detailed explanation-2: -ADH primarily affects the ability of the kidney to reabsorb water; when present, ADH induces expression of water transport proteins in the late distal tubule and collecting duct to increase water reabsorption.

Detailed explanation-3: -Antidiuretic hormone plays the biggest role on the collecting duct and distal tubule, allowing water to diffuse into the medulla by increasing the production of aquaporin proteins. These proteins become embedded in the membranes of the nephron epithelium and allow water to pass through the usually impermeable cells.