GENERAL HISTOLOGY

Detailed explanation-1: -This hormone triggers chemical reactions that ultimately insert aquaporin 2 water channels into the membrane of collecting duct cells. These channels allow water to be reabsorbed into the bloodstream, which makes the urine more concentrated.

Detailed explanation-2: -The main role of the collecting duct is the reabsorption of water, through the action of anti-diuretic hormone (ADH) and aquaporins. ADH is produced in the hypothalamus, and stored in the posterior pituitary gland until it is released.

Detailed explanation-3: -Water excretion by the kidney is regulated by the peptide hormone vasopressin. Vasopressin increases the water permeability of the renal collecting duct cells, allowing more water to be reabsorbed from collecting duct urine to blood.

Detailed explanation-4: -Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney’s collecting duct principal cells and in intracellular vesicles located throughout the cell. It is encoded by the AQP2 gene.

Detailed explanation-5: -The Role of Aquaporins in the Kidneys The majority of water reabsorption that occurs in the nephron is facilitated by the AQPs. Most of the fluid that is filtered at the glomerulus is then reabsorbed in the proximal tubule and the descending limb of the loop of Henle.