EXCRETORY SYSTEM
KIDNEY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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True
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False
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Either A or B
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None of the above
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Detailed explanation-1: -If the eGFR is between 30 and 44 mL/min/1.73 m2, metformin treatment should not be started. If metformin is already in use, a daily dose of ≤1, 000 mg is recommended. Metformin is contraindicated when the eGFR is <30 mL/min/1.73 m2. Renal function should be evaluated prior to any ICM-related procedures.
Detailed explanation-2: -In adults with type 2 diabetes, review the dose of metformin if the estimated glomerular filtration rate (eGFR) is below 45 ml/minute/1.73m2: Stop metformin if the eGFR is below 30 ml/minute/ 1.73m2.
Detailed explanation-3: -Metformin has been labeled unsafe for patients with moderate or severe CKD because of possible lactic acidosis associated with it. This label warning was recently revised to allow metformin use in patients who have stage 3-4 CKD.
Detailed explanation-4: -Metformin is contraindicated in “renal disease or renal dysfunction (eg, as suggested by serum creatinine levels ≥1.5 mg/dL [males], ≥1.4 mg/dL [females]) or abnormal creatinine clearance (CrCl).”