GENERAL HISTOLOGY

Detailed explanation-1: -In the nephron, your blood is filtered by the tiny blood vessels of the glomeruli and then flows out of your kidney through the renal vein.

Detailed explanation-2: -The glomerular filter is composed of three major cell types which perform a collective function of selective ultrafiltration of the blood plasma: the fenestrated endothelium, the intervening glomerular basement membrane and the epithelial podocytes (Brenner, et al., 1978, Rennke Venkatachalam.

Detailed explanation-3: -The process by which glomerular filtration occurs is called renal ultrafiltration. The force of hydrostatic pressure in the glomerulus (the force of pressure exerted from the pressure of the blood vessel itself) is the driving force that pushes filtrate out of the capillaries and into the slits in the nephron.

Detailed explanation-4: -The blood in the tuft is filter’s capsule. Then the filtrate of water and soluble substances enters the renal tubules of the nephron. Therefore it can be said that the glomerulus and Bowman’s capsule constitute the main structure of the kidney’s filtration system.

Detailed explanation-5: -The forces that govern filtration in the glomerular capillaries are the same as any capillary bed. Capillary hydrostatic pressure (Pc) and Bowman’s space oncotic pressure (i) favor filtration into the tubule, and Bowman’s space hydrostatic pressure (Pi) and capillary-oncotic pressure (c) oppose filtration.