GENERAL HISTOLOGY

Detailed explanation-1: -Diabetes and high blood pressure are the more common causes of CKD in adults. Other risk factors include heart disease, obesity, a family history of CKD, inherited kidney disorders, past damage to the kidneys, and older age. Managing blood sugar and blood pressure can help keep kidneys healthy.

Detailed explanation-2: -The pathophysiology of CKD associated hypertension is multi-factorial with different mechanisms contributing to hypertension. These pathogenic mechanisms include sodium dysregulation, increased sympathetic nervous system and alterations in renin angiotensin aldosterone system activity.

Detailed explanation-3: -High blood pressure can constrict and narrow the blood vessels in your kidneys, which reduces blood flow and stops the kidneys from working well. When this happens, the kidneys are not able to remove all wastes and extra fluid from your body.

Detailed explanation-4: -Risk factors Factors that can increase your risk of chronic kidney disease include: Diabetes. High blood pressure.

Detailed explanation-5: -Hypertension is both a cause and effect of CKD and affects the vast majority of CKD patients. Control of hypertension is important in those with CKD as it leads to slowing of disease progression as well as reduced CVD risk. Existing guidelines do not offer a consensus on optimal blood pressure (BP) targets.