GENERAL HISTOLOGY

Detailed explanation-1: -is the primary mechanism by which mammals convert ammonia to urea. Urea is made in the liver and excreted in urine.

Detailed explanation-2: -For a long time, urea has been considered to have negligible toxicity, in spite of its high absolute concentrations reported in the blood of patients with CRF, because short-term increases in urea concentration have been shown not to affect either acute organ function or acute clinical outcomes (9).

Detailed explanation-3: -Amino acids may also be metabolized through the liver to form urea, which is then excreted in the urine. Body protein stores can be converted back to essential and nonessential amino acids or may be metabolized, forming waste products and ions, which, as previously detailed, are excreted in the urine.

Detailed explanation-4: -Ammonia is toxic, and if it builds up, this can be very dangerous to our health. So, it is converted into urea in the liver. Urea is much less toxic than ammonia, but can still be toxic if it’s allowed to build up. So it is excreted from our body in urine.