GENERAL HISTOLOGY

EXCRETORY SYSTEM

KIDNEY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following are possible features of ADPKD?
A
Hypertension
B
Thyroid disease
C
Liver cysts
D
Intracranial cerebral aneurysms
Explanation: 

Detailed explanation-1: -Liver cysts. Liver cysts, which are fluid-filled cysts on the liver, are the most common nonkidney complication of ADPKD.

Detailed explanation-2: -Intracranial aneurysm-The most serious possible complication of PKD is a cerebral or brain aneurysm (a bulging blood vessel due to weakening of the blood vessel wall). Aneurysms can rupture, causing bleeding into the brain (subarachnoid hemorrhage).

Detailed explanation-3: -Causes of brain aneurysms The ADPKD genes PKD1 and PKD2 are now known to play a role in maintaining the structure of blood vessels. So this may explain why brain aneurysms affect several members of ADPKD families with certain genetic mutations.

Detailed explanation-4: -Bleeding. Hematoma expansion is a fatal complication. Cerebral vasospasm. Cerebral vasospasm resulting in cerebral ischemia is also one of the risk factors. Acute hydrocephalus. Focal seizures. 12-Feb-2021

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