GENERAL HISTOLOGY

Detailed explanation-1: -Scleroderma is believed to be an autoimmune disease. This means that it occurs in part because the body’s immune system begins to attack the connective tissues. People who have scleroderma may also have symptoms of another autoimmune disease-such as rheumatoid arthritis, lupus or Sjogren’s syndrome.

Detailed explanation-2: -Scleroderma is caused by the immune system attacking the connective tissue under the skin and around internal organs and blood vessels. This causes scarring and thickening of the tissue in these areas.

Detailed explanation-3: -The cause of morphea is unknown. It may be caused by an unusual reaction of your immune system. In people at increased risk of morphea, it could be triggered by injury to the affected area, medications, chemical toxins, an infection or radiation therapy. The condition isn’t contagious.