GENERAL HISTOLOGY

Detailed explanation-1: -The prickle cell layer (stratum spinosum) is the next layer (8-10 layers of cells). The cells in these layers have lots of desmosomes, which anchor the cells to each other, and contain thick tufts of intermediate filaments (keratin).

Detailed explanation-2: -The area where web-like pre-keratin filaments first appear is option (e) the stratum spinosum. The stratum spinosum is made up of several layers of keratinocytes (epidermal cells that form keratin). These cells are created due to the cell division of another layer of the epidermis: the stratum basale.

Detailed explanation-3: -Cells of the stratum spinosum begin the process of keratinization and continue into the stratum granulosum, which is covered by the outermost and most keratinized layer, the stratum corneum.