GENERAL HISTOLOGY

INTEGUMENTERY SYSTEM

DERMIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The basale layer which includes dividing keratinocytes that act as stem cells are located where in the skin?
A
bottom of the dermis
B
bottom of the hypodermis
C
bottom of the epidermis
D
none of these
Explanation: 

Detailed explanation-1: -The basal layer is the innermost layer of the epidermis, and contains small round cells called basal cell s. The basal cells continually divide, and new cells constantly push older ones up toward the surface of the skin, where they are eventually shed.

Detailed explanation-2: -Keratinocytes are found in the outermost layer of the skin, called the epidermis. The epidermis is composed of 95% keratinocyte cells. The cells in the basal layer are sometimes called basal keratinocytes or basal cells.

Detailed explanation-3: -The epidermal stem cells lie in the basal layer, attached to the basal lamina. Progeny that become committed to differentiation go through several rapid divisions in the basal layer, and then stop dividing and move out toward the surface of the skin.

Detailed explanation-4: -Epidermal stem cells lie in niches in the interfollicular epidermis, sebaceous gland, and in the bulge regions of hair follicles. These epidermal stem cells renew the epidermis, the sebaceous glands, and hair follicles after mature cells die.

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