GENERAL HISTOLOGY

Detailed explanation-1: -Collagen fibers form the extracellular framework of all tissues and are essential for tensile strength. The collagen molecules in these fibers are synthesized as larger precursor proteins, known as procollagens, from which large propeptide domains are enzymatically cleaved en bloc.

Detailed explanation-2: -The collagen fibers in the dermis are arranged in a crisscross pattern and held together by a substance called collagenase. That gives the skin its elasticity and strength.

Detailed explanation-3: -It occurs in skin, tendon, bone, vasculature, and organs. Variant: collagen fibre (British). Synonym: white fiber. See also: collagen, connective tissue, elastic fiber, reticular fiber.

Detailed explanation-4: -The stability of the collagen fibril is reinforced by hydrogen bonds that involve the hydroxyl groups of hydroxy-proline and hydroxylysine residues in the chains. These hydrogen bonds form crosslinks both within and between the individual collagen molecules in a fibril.