INTEGUMENTERY SYSTEM
DERMIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What is the important structural protein that Ella and other “Butterfly children” with epidermolysis bullosa are missing that holds the dermis and the epidermis together?
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Collagen
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Elastin
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Fibrin
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Reticular
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Explanation:
Detailed explanation-1: -In the skin laminin 332 is an essential component of the dermal-epidermal basement membrane. Its loss leads to the severe skin fragility disorder junctional epidermolysis bullosa Herlitz type, which restricts the life expectancy to few months or years.
Detailed explanation-2: -Keratinocytes: Keratinocytes produce the protein keratin, which is the main component of the epidermis.
Detailed explanation-3: -Mutations in the COL7A1 gene cause all forms of dystrophic epidermolysis bullosa. This gene provides instructions for making a protein that forms the pieces (subunits) of a larger protein called type VII collagen.
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