GENERAL HISTOLOGY

Detailed explanation-1: -(A) Somatosensory neurons are located in peripheral ganglia (trigeminal and dorsal root ganglia) located alongside the spinal column and medulla. Afferent neurons project centrally to the brainstem (Vc) and dorsal horn of the spinal cord and peripherally to the skin and other organs.

Detailed explanation-2: -The pain receptors are nociceptors. They are known to exist in muscle, joints, and skin. Each nociceptor has selective sensitivity to mechanical (muscle-fiber stretching), chemical (including lactic acid), and thermal stimuli.

Detailed explanation-3: -Nociceptors are found in the skin, muscles, and essentially all inner organs, and are specialized in detecting changes in the environment including mechanical forces like pressure and chemical changes such as inflammatory cytokines, pH, and temperature.