GENERAL HISTOLOGY

Detailed explanation-1: -A Langerhans cell (LC) is a tissue-resident dendritic cell of the skin. These cells contain organelles called Birbeck granules . They are present in all layers of the epidermis and are most prominent in the stratum spinosum.

Detailed explanation-2: -LCs are situated usually in the suprabasal layer of stratified squamous epithelia of oral mucosa and epidermis of skin. They constitute 3% of the cell population in epidermis. LCs are thought to act as antigen presenting cells (APCs) during initiation of immune responses.

Detailed explanation-3: -Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances.

Detailed explanation-4: -Langerhans cells, dendritic cells, are the skins first line defenders and play a significant role in antigen presentation. These cells need special stains to visualize, primarily found in the stratum spinosum.