GENERAL HISTOLOGY

Detailed explanation-1: -Cells of the stratum spinosum begin the process of keratinization and continue into the stratum granulosum, which is covered by the outermost and most keratinized layer, the stratum corneum.

Detailed explanation-2: -Stratum Granulosum: This layer contains up to 3-5 layers of keratinocytes. This stratum begins a process called keratinization. This is a process where the cells fill with keratin and the nucleus and organelles begin to disintegrate, killing the cells.

Detailed explanation-3: -The cells of the stratum granulosum (SGR) accumlate dense basophilic keratohyalin granules (seen on the close-up view). These granules contain lipids, which along with the desmosomal connections, help to form a waterproof barrier that functions to prevent fluid loss from the body.