GENERAL HISTOLOGY

Detailed explanation-1: -Stratum spinosum, 8-10 cell layers, also known as the prickle cell layer contains irregular, polyhedral cells with cytoplasmic processes, sometimes called “spines”, that extend outward and contact neighboring cells by desmosomes. Dendritic cells can be found in this layer.

Detailed explanation-2: -Skin is composed of two layers, the epidermis, the outer layer, which is derived from ectoderm, and the dermis, derived from mesoderm. The two layers are firmly adherent one to another with the dermis corresponding to the lamina propria of mucous membrane.

Detailed explanation-3: -This layer is composed of polyhedral keratinocytes. These are joined with desmosomes. Their spiny (Latin, spinosum) appearance is due to shrinking of the microfilaments between desmosomes that occurs when stained with H&E.

Detailed explanation-4: -Answer and Explanation: Langerhans cells are most common in the stratum spinosum layer of the epidermis, but they can be found in all layers in varying quantities. The stratum spinosum is found just above the stratum basale, the lowest layer of the epidermis.