GENERAL HISTOLOGY

Detailed explanation-1: -Corneodesmosomes are modified desmosomes present in the stratum corneum (SC). They are crucial for SC cohesion and, thus, constitute one of the pivotal elements of the functional protective barrier of human skin.

Detailed explanation-2: -The prickle cell layer (stratum spinosum) is the next layer (8-10 layers of cells). The cells in these layers have lots of desmosomes, which anchor the cells to each other, and contain thick tufts of intermediate filaments (keratin).

Detailed explanation-3: -The stratum corneum is composed of several layers of flattened, keratin-containing dead cells known as squames. The most superficial layer of skin, thestratum corneum, is composed of as many as 20 layers of flattened, keratinized cells with a thickened plasmalemma (Figs. 14.2, 14.5–14.7).

Detailed explanation-4: -The epidermis has 2 major barrier structures: stratum corneum, the outmost layer and tight junctions, intercellular junctions that seal adjacent keratinocytes in the stratum granulosum, found below the stratum corneum.