GENERAL HISTOLOGY

Detailed explanation-1: -A person’s skin color is determined primarily by the proportion of eumelanin to pheomelanin, the overall amount of melanin produced, and the number and size of melanosomes and how they are distributed. People with naturally darkly pigmented skin have melanosomes that are large and filled with eumelanin.

Detailed explanation-2: -Summary: The quantity and quality of melanin are regulating by the expression of genes. The enzyme tyrosinase is primarily responsible for the genetic mechanism that controls human skin color. Genetics determines constitutive skin color, which is reinforced by facultative melanogenesis and tanning reactions.

Detailed explanation-3: -Human skin color is a “polygenic” trait, meaning multiple gene loci are involved in its expression. At last count, the International Federation of Pigment Cell Society has determined that there are a total of 378 genetic loci involved in determining skin color in human and mice.

Detailed explanation-4: -The genetic mechanism behind human skin color is mainly regulated by the enzyme tyrosinase, which creates the color of the skin, eyes, and hair shades. Differences in skin color are also attributed to differences in size and distribution of melanosomes in the skin. Melanocytes produce two types of melanin.