GENERAL HISTOLOGY

Detailed explanation-1: -The nucleus contains the cell ‘s DNA and directs the synthesis of ribosomes and proteins. Found within the nucleoplasm, the nucleolus is a condensed region of chromatin where ribosome synthesis occurs.

Detailed explanation-2: -The major role of the nucleolus therefore, is the synthesis of rRNA and the assembly of ribosomes – the protein synthesis machinery of the cell.

Detailed explanation-3: -While the nucleolus can directly impact the rate of protein synthesis by regulating the levels of ribosome biogenesis it can also sense and respond to cellular stress by sequestering and releasing a variety of proteins affecting cell cycle and DNA repair.

Detailed explanation-4: -The nucleolus is a ribosome production factory, designed to fulfill the need for large-scale production of rRNAs and assembly of the ribosomal subunits.

Detailed explanation-5: -The nucleus (plural, nuclei) houses the cell’s genetic material, or DNA, and is also the site of synthesis for ribosomes, the cellular machines that assemble proteins.