GENERAL HISTOLOGY

Detailed explanation-1: -When proteins are destined to be part of the cell membrane or exported from the cell, the ribosomes assembling them attach to the endoplasmic reticulum, giving it a rough appearance. Smooth endoplasmic reticulum lacks ribosomes and helps synthesize and concentrate various substances needed by the cell.

Detailed explanation-2: -Regions of ER that lack bound ribosomes are called smooth endoplasmic reticulum, or smooth ER.

Detailed explanation-3: -The rough endoplasmic reticulum has on it ribosomes, which are small, round organelles whose function it is to make those proteins. Sometimes, when those proteins are made improperly, the proteins stay within the endoplasmic reticulum.

Detailed explanation-4: -Smooth endoplasmic reticulum (sER) is (a part of) endoplasmic reticulum that is tubular in form and lacks ribosomes. It is present in eukaryotic cells and is associated with lipid synthesis, carbohydrate metabolism, regulation of calcium concentration, and drug detoxification.