GENERAL HISTOLOGY

Detailed explanation-1: -Processing and assembly begin in the nucleolus, continue in the nucleoplasm and are completed in the cytoplasm.

Detailed explanation-2: -Ribosomes are mostly constructed in the cell nucleus, but the final stages of assembly occur in the cytoplasm of the cell. A protein called Nmd3 binds to the partly constructed ribosome to export it out of the nucleus.

Detailed explanation-3: -At the nucleolus, a long ribosomal RNA (rRNA) precursor molecule is transcribed from DNA, processed into three mature RNAs, and packaged together with specific proteins to make the large and small ribosomal subunits.

Detailed explanation-4: -An area inside the nucleus of a cell that is made up of RNA and proteins and is where ribosomes are made. Ribosomes help link amino acids together to form proteins. The nucleolus is a cell organelle.

Detailed explanation-5: -In eukaryotes, ribosome assembly is a complex process involving more than 200 assembly factors and spreads from the nucleolus to the cytoplasm. The process starts with the synthesis by the RNA Pol-I of the 35S pre-rRNA, which is co-transcriptionally bound and folded by ribosomal proteins and assembly factors.