GENERAL HISTOLOGY

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INTRODUCTION

CELL STRUCTURE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
When a cell is deprived of oxygen, its lysosomes tend to burst and release their contents into the cell. What will be the likely consequence for the cell?
A
Other organelles will assume lysosome functions.
B
The cell will produce more ER.
C
The cell will undergo division.
D
The cell will die due to internal damage.
Explanation: 

Detailed explanation-1: -So, the correct answer is ‘Cell dies’.

Detailed explanation-2: -So, the correct answer is ‘Autolysis’.

Detailed explanation-3: -If lysosomes get ruptured in a cell, the cell dies due to release of hydrolytic enzymes which destroys the cellular components.

Detailed explanation-4: -In the complete absence of oxygen, cells undergo cell death through apoptosis, and not necrosis. Apoptotic signaling during oxygen deprivation occurs through the release of cytochrome c and apaf-1 mediated caspase-9 activation. The upstream regulators of cytochrome c release are the Bcl-2 family members.

Detailed explanation-5: -Big lysosomes are easy to rupture, and the release of hydrolytic enzymes from ruptured lysosomes can cause plasma membrane disruption. Cell death can take place in morphologically distinct apoptotic and necrotic processes (29).

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