GENERAL HISTOLOGY

Detailed explanation-1: -When endothelial cell borders of leaky vessels are stained by the century-old silver nitrate method, gaps appear as stereotypic silver dots scattered along cell borders. These dots have a diameter of  1.5 µm, and they are most numer-ous ( 18/endothelial cell) in small postcapillary venules.

Detailed explanation-2: -Fenestrations are round or ovoid transcellular holes through the most attenuated part of the EnC cytoplasm. They are found in the endothelium of organs where a higher rate of exchange between intra-and extravascular compartments is required.

Detailed explanation-3: -One of these mechanisms is the formation of transient gaps between adjacent endothelial cell borders. Inflammatory mediators act on endothelium to reorganize the cytoskeleton, decrease the strength of proteins that connect cells together, and induce transient gaps between endothelial cells.

Detailed explanation-4: -What is the function of fenestrated capillaries? These capillaries move blood, fluids and waste throughout your body. The windows, or openings, in fenestrated capillaries allow larger molecules to pass through them. Fenestrated capillaries are especially important in your kidneys.