LIVER PANCREAS
LIVER
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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it will produce insulin and convert glucose to glycogen
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it will produce glucagon and convert glycogen to glucose
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it will convert glucose to glycogen and store this in hepatocytes
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it will convert glycogen to glucose and release this into the blood
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Detailed explanation-1: -The liver helps maintain blood glucose levels in response to the pancreatic hormones insulin and glucagon. After a meal, glucose enters the liver and levels of blood glucose rise. This excess glucose is dealt with by glycogenesis in which the liver converts glucose into glycogen for storage.
Detailed explanation-2: -Any excess glucose in the blood is turned into fat cells. The liver is one of the places in our bodies that stores this excess fat. Over time, liver cells are gradually replaced by fat cells, leading to non-alcohol related fatty liver disease . When we eat sugar, our bodies also release inflammatory chemicals.
Detailed explanation-3: -Elevated insulin levels initiate the insulin signaling cascade in liver that suppresses glycogen breakdown and promotes glycogen storage and lipogenesis. Insulin’s action in the liver is counter-regulated by glucagon, which promotes glycogen breakdown and gluconeogenesis when nutrients are not available.
Detailed explanation-4: -The liver supplies sugar or glucose by turning glycogen into glucose in a process called glycogenolysis. The liver also can manufacture necessary sugar or glucose by harvesting amino acids, waste products and fat byproducts. This process is called gluconeogenesis.
Detailed explanation-5: -In the fed state, glucose enters hepatocytes via GLUT2 and is phosphorylated by glucokinase and used to synthesize glycogen by glycogen synthase (4). In the fasted state, glycogen is hydrolyzed by glycogen phosphorylase to generate glucose (glycogenolysis) (Fig.