GENERAL HISTOLOGY

Detailed explanation-1: -Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.

Detailed explanation-2: -Hepatic macrophages, consisting of liver resident Kupffer cells (KCs) and monocyte-derived macrophages (MoMs), play a central role in maintaining homeostasis of the liver as well as contributing to the progression of acute or chronic liver injury (1).

Detailed explanation-3: -Their name is derived from Karl Wilhelm von Kupffer, a German anatomist who was the first to describe them in 1876. 1. Initially, he referred to these cells as sternzellen because of the star-shape of the cells. He described the cells as specialized endothelial cells of the liver capable of phagocytosis.