GENERAL HISTOLOGY

Detailed explanation-1: -We conclude that in rats Kupffer cells rapidly remove RBC-derived vesicles from the circulation, mainly by scavenger receptors. The same mechanism is likely to be responsible for the elimination of human RBC vesicles, thereby constituting an important pathway for the breakdown of RBCs in humans.

Detailed explanation-2: -The function of Kupffer cells is to break down red blood cells through phagocytosis, liberating the globin chains and the heme component for further metabolic processing and re-use. Kupffer cells also play an essential role in innate immunity.

Detailed explanation-3: -Apart from clearing bacteria, Kupffer cells are also responsible for recycling hemoglobin by destroying senescent red blood cells through phagocytic action.

Detailed explanation-4: -Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.