GENERAL HISTOLOGY

Detailed explanation-1: -Kupffer cells play a critical role in the innate immune response; their localization in the hepatic sinusoid allows them to efficiently phagocytize pathogens entering from the portal or arterial circulation.

Detailed explanation-2: -The function of Kupffer cells is to break down red blood cells through phagocytosis, liberating the globin chains and the heme component for further metabolic processing and re-use. Kupffer cells also play an essential role in innate immunity.

Detailed explanation-3: -Thus, the main role of Kupffer cells is to protect the body by removing potentially harmful substances from the blood. In addition, Kupffer cells function to remove and destroy old red blood cells.

Detailed explanation-4: -Kupffer cell, any of the stellate (star-shaped) cells in the linings of the liver sinusoids. The sinusoids are microscopic blood channels. The Kupffer cells are phagocytic, i.e., capable of ingestion of other cells and of foreign particles.