GENERAL HISTOLOGY

Detailed explanation-1: -Kupffer cells are resident liver macrophages and play a critical role in maintaining liver functions. Under physiological conditions, they are the first innate immune cells and protect the liver from bacterial infections.

Detailed explanation-2: -Kupffer cells (KCs) are macrophages that reside in sinusoids in proximity to ECs. They serve a physiological function to remove senescent cells and particulates, including bacteria and their products.

Detailed explanation-3: -In the liver, macrophages are called Kupffer cells. They line tiny blood vessels in the liver, where they do a lot of things, including maintaining the body’s iron levels and clearing away endotoxins produced by gut bacteria.

Detailed explanation-4: -Unlike other tissue macrophages, which must be continually renewed by circulating monocytes, these monocyte-derived Kupffer cells are capable of self-renewal once a population is established.

Detailed explanation-5: -Their name is derived from Karl Wilhelm von Kupffer, a German anatomist who was the first to describe them in 1876. 1. Initially, he referred to these cells as sternzellen because of the star-shape of the cells. He described the cells as specialized endothelial cells of the liver capable of phagocytosis.