GENERAL HISTOLOGY

Detailed explanation-1: -Diabetic ketoacidosis (DKA) is a life-threatening problem that affects people with diabetes. It occurs when the body starts breaking down fat at a rate that is much too fast. The liver processes the fat into a fuel called ketones, which causes the blood to become acidic.

Detailed explanation-2: -DKA develops when your body doesn’t have enough insulin to allow blood sugar into your cells for use as energy. Instead, your liver breaks down fat for fuel, a process that produces acids called ketones. When too many ketones are produced too fast, they can build up to dangerous levels in your body.

Detailed explanation-3: -The most common causes are underlying infection, disruption of insulin treatment, and new onset of diabetes. (See Etiology.) DKA is defined clinically as an acute state of severe uncontrolled diabetes associated with ketoacidosis that requires emergency treatment with insulin and intravenous fluids.

Detailed explanation-4: -Hypoglycemia is the most common complication of diabetic ketoacidosis while being treated, occurring in an estimated 5–25% of patients with DKA. [37] Acute adverse outcomes of hypoglycemia include seizures, arrhythmias, and cardiovascular events. Hourly blood sugar monitoring is needed in the acute phase of treatment.

Detailed explanation-5: -The most common complications of DKA and HHS include hypoglycemia and hypokalemia due to overzealous treatment with insulin and bicarbonate (hypokalemia), but these complications occur infrequently with current low dose insulin regimens.