GENERAL HISTOLOGY

Detailed explanation-1: -The human pancreas secretes an impressive amount of sodium-bicarbonate–rich fluid with each meal. The majority of fluid and bicarbonate in pancreatic juice arises from the pancreatic duct cells, although they comprise only 5% of the pancreatic mass.

Detailed explanation-2: -In contrast, ductal cells secrete bicarbonate which will elevate the intraluminal pH. Our hypothesis is that protons may stimulate the ductal bicarbonate secretion via acid sensing receptors (ASR), which can elevate the pH in the ductal lumen setting the luminal pH to 8.0.

Detailed explanation-3: -Ductal cells of the pancreas form the epithelial lining of the branched tubes that deliver enzymes produced by pancreatic acinar cells into the duodenum. In addition, these cells secrete bicarbonate that neutralizes stomach acidity.

Detailed explanation-4: -Pancreas secretes fluid rich in digestive enzymes and bicarbonate. The alkaline secretion is important in buffering of acid chyme entering duodenum and for activation of enzymes.