GENERAL HISTOLOGY

Detailed explanation-1: -Heavy drinking over many years can cause repeated episodes of acute pancreatitis. Acute pancreatitis is usually a short-term condition, but it can recur if you continue to drink alcohol. Over time, repeated inflammation causes permanent damage to the pancreas, resulting in chronic pancreatitis.

Detailed explanation-2: -If you have chronic pancreatitis, the digestive enzymes that would normally travel by tubes inside your pancreas and empty into your upper intestine, become trapped inside your pancreas. This causes pain and scarring. The trapped enzymes slowly cause severe damage to your pancreas.

Detailed explanation-3: -In people with chronic pancreatitis, the pancreas may not function normally, leading to difficulty processing fat in the diet (exocrine pancreatic insufficiency). This can cause loose, greasy, foul-smelling stools that are difficult to flush. This can lead to vitamin and nutrient deficiencies, including weight loss.

Detailed explanation-4: -Chronic pancreatitis is a progressive inflammatory disorder that leads to irreversible destruction of exocrine and endocrine pancreatic parenchyma caused by atrophy and/ or replacement with fibrotic tissue. Functional consequences include severe abdominal pain, diabetes mellitus, and malabsorption.