GENERAL HISTOLOGY

Detailed explanation-1: -As noted earlier, the classic liver lobule is a hexagonal solid in which the blood flows from the periphery of the lobule to the center, and bile flows in the opposite direction (Fig. 18.4).

Detailed explanation-2: -Answer and Explanation: Blood and bile flow in opposite directions because they have opposite endpoints. Blood flows towards the central vein which will ultimately put blood into the inferior vena cava heading towards the heart.

Detailed explanation-3: -Hepatic blood flow. In the hepatic lobule, blood enters the lobule via the portal vein and hepatic artery, located within portal triads (PT). This venous and arterial blood then combines and drains through hepatic sinusoids towards the central vein (CV). The direction of blood flow is shown as red arrows.

Detailed explanation-4: -Bile flows towards the peripheral portal triad, enter hepatic ducts and exit the liver. Arterial and venous blood flows towards the central venule; Filtered, deoxygenated blood drains to the hepatic veins and to the inferior vena cava to re-enter general circulation.

Detailed explanation-5: -The first is the hepatic artery which delivers oxygenated blood from the general circulation. The second is the hepatic portal vein delivering deoxygenated blood from the small intestine containing nutrients. The blood flows through the liver tissue to the hepatic cells where many metabolic functions take place.