GENERAL HISTOLOGY

Detailed explanation-1: -Food molecules, primarily proteins and fats, stimulate these cells and CCK is released into the blood stream(1, 2). CCK stimulates pancreatic secretion by two possible mechanisms. First, CCK binds CCK-1 receptors on pancreatic acinar cells and stimulates release of enzymes.

Detailed explanation-2: -The gastrointestinal peptide cholecystokinin (CCK) causes the release of pancreatic digestive enzymes and growth of the normal pancreas. Exogenous CCK administration has been used in animal models to study pancreatitis and also as a promoter of carcinogen-induced or Kras-driven pancreatic cancer.

Detailed explanation-3: -Cholecystokinin is secreted by cells of the upper small intestine. Its secretion is stimulated by the introduction of hydrochloric acid, amino acids, or fatty acids into the stomach or duodenum.

Detailed explanation-4: -Pancreatic amylase secretion is stimulated by food molecules such as sodium oleate, monoglycerides, peptides, and amino acids (particularly tryptophan and phenylalanine) (50, 88, 188, 215-217).

Detailed explanation-5: -The physiological actions of CCK include stimulation of pancreatic secretion and gallbladder contraction, regulation of gastric emptying, and induction of satiety. Therefore, in a highly coordinated manner, CCK regulates the ingestion, digestion, and absorption of nutrients.