GENERAL HISTOLOGY

Detailed explanation-1: -During allergic reactions, basophils release two enzymes, histamine and heparin. Histamine enlarges your blood vessels to improve blood flow and heal the affected area. Histamine opens pathways for other cells in your immune system to quickly target and respond to the allergen.

Detailed explanation-2: -Basophils migrate to injury sites and cross the capillary endothelium to accumulate in the damaged tissue, where they discharge granules that contain histamine (dilates blood vessels) and heparin (prevents clotting).

Detailed explanation-3: -Interestingly, it has been demonstrated that eosinophil-derived MBP directly activates the release of histamine and LTC4 from human basophils [15, 25].

Detailed explanation-4: -Mast cells is a type of granular basophil cells in the connective tissue, that releases heparin, histamine and serotonin during inflammation and allergic reactions.