GENERAL HISTOLOGY

Detailed explanation-1: -The epidermis functions as a physical barrier to the external environment and works to prevent loss of water from the skin.

Detailed explanation-2: -Your skin is made up of layers, each of which performs important functions in protecting your body. The outermost layer, called the stratum corneum, is often described as a brick wall . It consists of tough skin cells called corneocytes that are bound together by mortar-like lipids. This is your skin barrier.

Detailed explanation-3: -In the skin there are the mechanical barriers of the stratum corneum (SC) [1] and the tight junctions (TJs) in the interfollicular epidermis [2, 3], and in hair follicles (HFs) [4].