LYMPHATIC
LYMPHATIC SYSTEM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Which is the site where T cells become immunocompetent?
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spleen
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thymus
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lymph nodes
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bone marrow
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Explanation:
Detailed explanation-1: -These lymphocytes develop immunocompetence in the primary lymphoid organs: thymus, for the T lymphocytes and bursa of Fabricius (in birds), on its equivalent (in mammals), for B lymphocytes.
Detailed explanation-2: -The thymus is the primary site of T cell development, where progenitors from the bone marrow lacking CD4+ and CD8+ coreceptor expression undergo T cell receptor (TCR) rearrangement to generate CD4+CD8+ double positive (DP) thymocytes.
Detailed explanation-3: -T cell development occurs in the thymus; the thymic microenvironment directs differentiation as well as positive and negative selection.
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