GENERAL HISTOLOGY

Detailed explanation-1: -The maturation of T-lymphocytes or the T-cells takes place in the thymus gland. Both the lymphocytes, i.e., the B-lymphocytes and the T-lymphocytes are formed in the red bone marrow by the process of hematopoiesis and the maturation of the B-lymphocytes takes place in the bone marrow itself.

Detailed explanation-2: -Generation of T Cells Lymphoid progenitors which have developed from hematopoietic stem cells in the bone marrow migrate to the thymus to complete their antigen-independent maturation into functional T cells . In the thymus, T cells develop their specific T cell markers, including TCR, CD3, CD4 or CD8, and CD2.

Detailed explanation-3: -The NK/T precursors migrate to the thymus, where thymocyte development proceeds in three multipartite phases: the DN phase (neither CD4 nor CD8 appears on the thymocyte surface), the DP phase (both CD4 and CD8 are present), and the SP phase (either CD4 or CD8 is present on the surface of a mature T cell).