GENERAL HISTOLOGY

LYMPHATIC

LYMPHATIC SYSTEM

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following is the foot soldier of cell-mediated immunity and has CD8 markers?
A
B cells (plasma cells)
B
cytotoxic killer T cells
C
helper T cells
D
natural killer cells
Explanation: 

Detailed explanation-1: -A cytotoxic T cell (CD8+ T cell) is a type of T cell responsible for eliminating substances the immune system identifies as harmful. Cytotoxic T cells play a critical role in limiting infections and bacteria in the body.

Detailed explanation-2: -Cytotoxic CD8 T cells carry out their killing function by releasing two types of preformed cytotoxic protein: the granzymes, which seem able to induce apoptosis in any type of target cell, and the pore-forming protein perforin, which punches holes in the target-cell membrane through which the granzymes can enter.

Detailed explanation-3: -Recently, a role for CD8 T cells in the innate immune response has become apparent. Independent of T cell receptor ligation, CD8 T cells can mount a response against pathogens by secreting cytokines and can defend against tumors by directly killing transformed cells.

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