GENERAL HISTOLOGY

Detailed explanation-1: -The majority of mature B cells outside of the GALT reside within lymphoid follicles of the spleen and lymph nodes, where they encounter and respond to T cell–dependent foreign antigens bound to follicular dendritic cells (DCs), proliferate, and either differentiate into plasma cells or enter GC reactions.

Detailed explanation-2: -The lymph node is composed of sinuses that allow travel of lymph, the cortex and paracortex composed of T and B lymphocytes, and the medulla consisting of plasma cells and macrophages (Figure 7). Unactivated lymphocytes enter lymph nodes from the blood through high endothelial venules in the cortex.

Detailed explanation-3: -Lymph nodes have 2 distinct regions, the cortex and the medulla. The cortex contains follicles, which are collections of lymphocytes. At the center of the follicles is an area called germinal centers that predominantly host B-lymphocytes while the remaining cells of the cortex are T-lymphocytes.