GENERAL HISTOLOGY

Detailed explanation-1: -Acetylcholine binds to specialized receptors (ligand-gated channels) at the postsynaptic terminal (sarcolemma). The opening of these channels causes an influx of Na+ ions into the cell, leading to the threshold potential and the generation of end-plate potential at the neuromuscular junction (Figure 6).

Detailed explanation-2: -The “motor end plate” part of the sarcolemma contains acetylcholine (ACh) receptors. This motor end plate (or end plate) is formed where the motor neuron meets the muscle fiber, therefore, it is a synapse that allows AP transmission.

Detailed explanation-3: -Embedded in the sarcolemma (= fiber membrane) at the neuromuscular junction are (nicotinic) receptors for acetylcholine (ACh). This is the neurotransmitter that is released by the terminal branches of a motor neuron.

Detailed explanation-4: -The acetylcholine binds to the nicotinic receptors concentrated on the motor end plate, a specialized area of the muscle fibre’s post-synaptic membrane. This binding causes the nicotinic receptor channels to open and let sodium ions enter the muscle fibre.