GENERAL HISTOLOGY

Detailed explanation-1: -The sarcomere is the smallest functional unit of a skeletal muscle fiber and is a highly organized arrangement of contractile, regulatory, and structural proteins. It is the shortening of these individual sarcomeres that lead to the contraction of individual skeletal muscle fibers (and ultimately the whole muscle).

Detailed explanation-2: -The basic histologic component of all skeletal muscles is the skeletal muscle cells, also known as muscle fibers or myofibers. Myofibers are grouped into larger units called muscle fascicles, which are enveloped together by connective tissue (called epimysium) into anatomically recognized muscles.

Detailed explanation-3: -The smallest contractile unit of skeletal muscle is the muscle fiber or myofiber, which is a long cylindrical cell that contains many nuclei, mitochondria, and sarcomeres (Figure 1) [58]. Each muscle fiber is surrounded by a thin layer of connective tissue called the endomysium.