GENERAL HISTOLOGY

Detailed explanation-1: -Muscle weakness is commonly due to lack of exercise, ageing, muscle injury or pregnancy. It can also occur with long-term conditions such as diabetes or heart disease. There are many other possible causes, which include stroke, multiple sclerosis, depression, fibromyalgia and chronic fatigue syndrome (ME).

Detailed explanation-2: -Muscle fatigue is defined as a decrease in maximal force or power production in response to contractile activity. 5. It can originate at different levels of the motor pathway and is usually divided into central and peripheral components.

Detailed explanation-3: -Substrates are depleted during exercise, resulting in a lack of intracellular energy sources to fuel contractions. In essence, the muscle stops contracting because it lacks the energy to do so.