GENERAL HISTOLOGY

MUSCLE

SKELETAL MUSCLE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Muscle fatigue is most likely due to an accumulation of
A
citric acid
B
lactic acid
C
creatine
D
myosin
Explanation: 

Detailed explanation-1: -Lactic acid is formed and accumulated in the muscle under conditions of high energy demand, rapid fluctuations of the energy requirement and insufficient supply of O2. During intense exercise sustained to fatigue muscle pH decreases to about 6.4-6.6.

Detailed explanation-2: -Intracellular acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue.

Detailed explanation-3: -Accumulation of lactic acid in the muscles causes cramps.

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